INTERNATIONAL RESEARCH
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
C.E. Geyer, Jr.1,2 ∙ J.E. Garber3 ∙ R.D. Gelber3,4,5 ∙ G. Yothers1,6 ∙ M. Taboada7 ∙ L. Ross8 ∙ P. Rastogi1,2 ∙ K. Cui9 ∙ A. Arahmani10 ∙ G. Aktan11 ∙ A.C. Armstrong12 ∙ M. Arnedos13,14 ∙ J. Balmaña15 ∙ J. Bergh16 ∙ J. Bliss17 ∙ S. Delaloge18 ∙ S.M. Domchek19 ∙ A. Eisen20 ∙ F. Elsafy7 ∙ L.E. Fein21 ∙ A. Fielding9 ∙ J.M. Ford22 ∙ S. Friedman23 ∙ K.A. Gelmon24 ∙ L. Gianni25,26 ∙ M. Gnant27 ∙ S.J. Hollingsworth28 ∙ S.-A. Im29 ∙ A. Jager30 ∙ Ó. Þ Jóhannsson31 ∙ S.R. Lakhani32 ∙ W. Janni33 ∙ B. Linderholm34,35 ∙ T.-W. Liu36 ∙ N. Loman37 ∙ L. Korde38 ∙ S. Loibl39,40 ∙ P.C. Lucas1,41 ∙ F. Marmé42 ∙ E. Martinez de Dueñas43 ∙ R. McConnell8 ∙ K.-A. Phillips44,45 ∙ M. Piccart46 ∙ G. Rossi47 ∙ R. Schmutzler48 ∙ E. Senkus49 ∙ Z. Shao50 ∙ P. Sharma51 ∙ C.F. Singer52 ∙ T. Španić53,54 ∙ E. Stickeler55 ∙ M. Toi56 ∙ T.A. Traina57 ∙ G. Viale58 ∙ G. Zoppoli59,60 ∙ Y.H. Park61 ∙ R. Yerushalmi62,63 ∙ H. Yang64 ∙ D. Pang65 ∙ K.H. Jung66 ∙ A. Mailliez67 ∙ Z. Fan68 ∙ I. Tennevet69 ∙ J. Zhang70 ∙ T. Nagy71 ∙ G.S. Sonke72 ∙ Q. Sun73 ∙ M. Parton74 ∙ M.A. Colleoni75 ∙ M. Schmidt76 ∙ A.M. Brufsky1,2 ∙ W. Razaq77 ∙ B. Kaufman78,† ∙ D. Cameron79 ∙ C. Campbell80 ∙ A.N.J. Tutt81,82 andrew.tutt@icr.ac.uk and the OlympiA Clinical Trial Steering Committee and Investigators
Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women
Nina Mars, MD, PhD, Sini Kerminen, PhD, Max Tamlander, MD, Matti Pirinen, PhD, Eveliina Jakkula, MD, PhD, Kirsimari Aaltonen, MD, PhD, Tuomo Meretoja, MD, PhD, Sirpa Heinävaara, PhD, Elisabeth Widén, MD, PhD, and Samuli Ripatti, PhD, on behalf of FinnGen
Polygenic risk scores stratify breast cancer risk among women with benign breast disease
Mark E Sherman, MD , Stacey J Winham, PhD , Robert A Vierkant, MS , Bryan M McCauley, BS , Christopher G Scott, MS , Sarah Schrup, BS , Mia M Gaudet, PhD , Melissa A Troester, PhD , Sandhya Pruthi, MD , Derek C Radisky, PhD , Amy C Degnim, MD , Fergus J Couch, PhD , Manjeet K Bolla, MSc , Qin Wang, MSc , Joe Dennis, MSc , Kyriaki Michailidou, PhD , Pascal Guenel, PhD , Therese Truong, PhD , Jenny Chang-Claude, PhD , Nadia Obi, PhD , Kristan J Aronson, PhD , Rachel Murphy, PhD , Montserrat Garcia-Closas, MD, DrPH , Stephen Chanock, MD , Thomas Ahearn, PhD , Xiaohong Yang, PhD , Alison M Dunning, PhD , Nasim Mavaddat, PhD , Paul D P Pharoah, PhD , Douglas F Easton, PhD , Celine M Vachon, PhD
Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial
Kirkpatrick B. Fergus, Rachel S. Heise, Lisa Madlensky, Allison Fiscalini, Leah Sabacan, Sarah Theiner, Shreya Kapoor, Irene A. Soto, Amie Blanco, Katherine Ross, Deborah Goodman-Gruen, Maren Scheuner, Donglei Hu, Diane Heditsian, Susie Brain, Vignesh A. Arasu, Andrea Kaster, Lisa Chapa, Olufunmilayo I. Olopade, Martin Eklund, Jeffrey A. Tice, Elad Ziv, Laura van ‘t Veer, Laura J. Esserman, Yiwey Shieh & The Athena/WISDOM Network Collaborators and Advocate PartnersShow fewer authors
Association of a polygenic risk score with risk of abnormal ultrasound findings and ovarian cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Sarah Phillips, Rebecca Landy, Clara Bodelon, Mitchell J. Machiela, Sarah M. Temkin, and Nicolas Wentzensen
Characterizing somatic mutations in ovarian cancer germline risk regions
Ping-Hung Lai, Jonathan P. Tyrer, Paul Pharoah, Simon A. Gayther, Michelle R. Jones & Pei-Chen Peng
ESGO–ESMO–ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease
J.A. Ledermann1,† clinicalguidelines@esmo.org ∙ X. Matias-Guiu2,3,4,† admin@esp-pathology.org ∙ F. Amant5,6 ∙ N. Concin7,8 ∙ B. Davidson9,10 ∙ C. Fotopoulou11 ∙ A. González-Martin12 ∙ C. Gourley13 ∙ A. Leary14 ∙ D. Lorusso15,16 ∙ S. Banerjee17 ∙ L. Chiva18 ∙ D. Cibula19 ∙ N. Colombo20,21 ∙ S. Croce22 ∙ A.G. Eriksson10,23 ∙ C. Falandry24,25 ∙ D. Fischerova19 ∙ P. Harter8,26 ∙ F. Joly27 ∙ C. Lazaro28 ∙ C. Lok6 ∙ S. Mahner26,29 ∙ F. Marmé26,30,31 ∙ C. Marth7 ∙ W.G. McCluggage32 ∙ I.A. McNeish11 ∙ P. Morice33 ∙ S. Nicum1 ∙ A. Oaknin34 ∙ J.A. Pérez-Fidalgo35 ∙ S. Pignata36 ∙ P.T. Ramirez37 ∙ I. Ray-Coquard38 ∙ I. Romero39 ∙ G. Scambia15,16 ∙ J. Sehouli40,41 ∙ R. Shapira-Frommer42 ∙ S. Sundar43,44 ∙ D.S.P. Tan45,46,47,48 ∙ C. Taskiran49 ∙ W.J. van Driel6 ∙ I. Vergote5 ∙ F. Planchamp50 ∙ C. Sessa51 ∙ A. Fagotti15,16
Breast Cancer Risk and Breast-Cancer-Specific Mortality following Risk-Reducing Salpingo-Oophorectomy in BRCA Carriers: A Systematic Review and Meta-Analysis
Gaba F, Blyuss O, Tan A, Munblit D, Oxley S, Khan K, Legood R, Manchanda R.
BRCA1/ BRCA2 mutation spectrum analysis in South Asia: a systematic review
Kharel S, Shrestha S, Yadav S, Shakya P, Baidya S, Hirachan S.
Editorial: Hereditary Breast and Ovarian Cancer: Current Concepts of Prevention and Treatment
Grabenstetter A, Lazaro C, Turashvili G. Editorial
Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland
Pallonen, T.AS., Lempiäinen, S.M.M., Joutsiniemi, T.K. et al
Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis
Yoshida, R.
Patient and Clinician Decision Support to Increase Genetic Counseling for Hereditary Breast and Ovarian Cancer Syndrome in Primary Care: A Cluster Randomized Clinical Trial
Kukafka R, Pan S, Silverman T, et al.
Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high-risk Chinese individuals
Shao D, Cheng S, Guo F, et al.
Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations
Tsaousis GN, Papadopoulou E, Apessos A, et al.
Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women
Breast Cancer Association Consortium
Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation
Mark Robson, M.D., Seock-Ah Im, M.D., Ph.D., Elżbieta Senkus, M.D., Ph.D., Binghe Xu, M.D., Ph.D., Susan M ,et al.
A Population-Based Study of Genes Previously Implicated in Breast Cancer
Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
A.N.J. Tutt, J.E. Garber, B. Kaufman, G. Viale, D. Fumagalli, P. Rastogi,
R.D. Gelber, E. de Azambuja, A. Fielding, J. Balmaña, S.M. Domchek,
K.A. Gelmon, S.J. Hollingsworth, L.A. Korde ,et al.
BRCA1/2 Mutations in Vietnamese Patients with Hereditary Breast and Ovarian Cancer Syndrome
Le TN, Tran VK, Nguyen TT, et al
Editorial: Hereditary Breast and Ovarian Cancer: Current Concepts of Prevention and Treatment
Genetic, clinic and histopathologic characterization of BRCA-associated hereditary breast and ovarian cancer in southwestern Finland
Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis
Patient and Clinician Decision Support to Increase Genetic Counseling for Hereditary Breast and Ovarian Cancer Syndrome in Primary Care A Cluster Randomized Clinical Trial
Prevalence of hereditary breast and ovarian cancer (HBOC) predisposition gene mutations among 882 HBOC high‐risk Chinese individuals
Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations
BRCA1/2 Mutations in Vietnamese Patients with Hereditary Breast and Ovarian Cancer Syndrome
Screening of over 1000 Indian patients with breast and/or ovarian cancer with a multi-gene panel: prevalence of BRCA1/2 and non-BRCA mutations. Breast Cancer Res Treat
Breast Cancer Risk and Breast-Cancer-Specific Mortality following Risk-Reducing Salpingo-Oophorectomy in BRCA Carriers: A Systematic Review and Meta-Analysis
Gaba F, Blyuss O, Tan A, Munblit D, Oxley S, Khan K, Legood R, Manchanda R.
BRCA1/ BRCA2 mutation spectrum analysis in South Asia: a systematic review
Kharel S, Shrestha S, Yadav S, Shakya P, Baidya S, Hirachan S.